Integrated 16s rRNA gene sequencing of gut microbiota from two IgA nephropathy mouse experimental cohorts with Yishen Huashi granule intervention

The two animal batches were sequenced and analyzed together to characterize microbial community alterations associated with IgA nephropathy modeling and Yishen Huashi granule intervention.The dataset was generated to evaluate whether Yishen Huashi granules reshape intestinal microbial composition in IgA nephropathy mouse models and to identify microbial taxa that may contribute to their therapeutic effects.

Downstream analyses included microbial community structure, differential taxonomic profiling, beta-diversity analysis, and identification of treatment-associated microbial signatures, with particular attention to Bifidobacterium-related changes observed across experimental settings.