Data · dataset · 2026
A serum-stable antimicrobial peptide-based delivery platform for selective treatment of non-targetable and chemo-resistant tumours
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32641962.v1
Antibody–drug conjugates have transformed cancer therapy but remain limited by their dependence on internalizing antigens, poor applicability to untargetable tumours, and susceptibility to drug resistance.
Description
Therefore, a modular antimicrobial peptide (AMP)-based therapeutic system, conjugate 270, was presented, which integrates three optimized components: a selectivity-enhanced AMP core via a membrane affinity reconstruction strategy, a conformation-driven PEGylated blocker to minimize off-target effects, and an N-terminal cap to improve stability in human serum.
By targeting non-endocytic membrane surface receptors via small-molecule ligands, conjugate 270 exhibited potent and selective cytotoxicity against target tumour cells, effectively eliminating the majority of tumour cells within a few hours. Meanwhile, it exhibited high serum stability, minimal haemolysis, and negligible cytotoxicity toward normal cells at therapeutic concentrations. Mechanistic studies confirmed ligand-dependent membrane localization, rapid depolarization and disruption, along with mitochondrial dysfunction.
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Moreover, it demonstrated significant therapeutic efficacy against four cell lines resistant to conventional chemotherapeutic agents. While additional in vivo validation is warranted, this work lays the foundation for a flexible AMP-based approach to address conventional untargetable and drug-resistant cancers.<br><br><i>Thesis is embargoed until 31 December 2030.</i>
Links
Where it is published
- DOI doi.org/10.17034/32641962.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Cancer 75%
Provenance · 3 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32641962 | 9 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32641962 | 9 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32641962 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |