Excel · study · 2026
The immune response to a biodegradable polymer and corresponding collagen regeneration
Listed in NCBI GEO
In this study, we used RNA sequencing to investigate the molecular mechanisms underlying site-specific tissue regeneration induced by an injectable thermosensitive PLGA-PEG-PLGA hydrogel (T-gel) in rats.
Description
We compared the transcriptomic profiles of skin tissue following intradermal or subcutaneous injection of T-gel, with saline injections at corresponding sites as controls. This is evidenced by a greater number of differentially expressed genes and a significant enrichment of extracellular matrix organization and collagen biosynthesis pathways in the intradermal group compared to the subcutaneous group.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325546 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325546 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1440444 ncbi.nlm.nih.gov/bioproject/PRJNA1440444 ↗
project · from NCBI GEO
- PubMed 42006002 pubmed.ncbi.nlm.nih.gov/42006002 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE325546 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |