Data · dataset · 2026
<p>Robust disease signatures and enriched biological programs in osteoarthritis and osteoporosis.</p>
Listed in UCL Research Data Repository
<p>(A) OA signature genes prioritized by integration across four OA bulk cohorts.
Description
The panel presents the highest-ranked genes and selected genes representing antigen presentation, inflammatory signaling, and matrix or tissue-response processes. (B) OP signature genes prioritized across four OP bulk cohorts, together with selected genes representing bone remodeling, immune and antigen-presentation activity, and bone or matrix adaptation.
(C) Representative Gene Ontology biological processes enriched in the OA signature. (D) Representative Gene Ontology biological processes enriched in the OP signature. (E) Cross-cohort effects of the displayed genes.
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Cell color indicates the signed within-dataset effect, asterisks indicate cohort-level FDR < 0.05, and NA indicates unavailable mapping. Complete cohort-level gene and pathway results are provided in the accompanying data files. OA, osteoarthritis; OP, osteoporosis; GO, Gene Ontology; FDR, false discovery rate.</p>
Links
Where it is published
- DOI doi.org/10.1371/journal.pone.0359583.g002 ↗
DOI / persistent id · from rdr ucl ac uk
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from rdr ucl ac uk
Topics
- From keywords
- Biochemistry and cell biology · Earth & Environmental Science · Genetics · Immunology · Infectious diseases · Life Sciences · Medicine & Health
- Inferred from text
- Disease 75%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| UCL Research Data Repository | oai:figshare.com:article/34048607 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · rdr ucl ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:320211 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:group:3101 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3105 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].anzsrc:group:3204 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| description | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| title | source · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | /metadata/dc/title |