The data that support the findings of this study are available from the corresponding author upon reasonable request. Additionally, all relevant data are included in the manuscript.

Here, we fabricated a natural polymer-based dressing (EC/PVMA-LA) via electrospinning by incorporating L-arginine through dynamic Schiff base linkages. The dressing exhibited self-programming microstructures with tunable mechanical properties, achieving low stress (0.85 MPa) and high extensibility (277.63% elongation).

EC/PVMA-LA0.4 demonstrated excellent biocompatibility (hemolysis rate 2.22%, L929 viability >100%) and 100% antibacterial efficacy. In vivo studies revealed accelerated wound closure with only 7.91% residual area by day 14, outperforming commercial dressings. This integrated platform offers a promising strategy for advanced wound care.