Data · dataset · 2026
Hypothalamic amyloid levels are associated with early sex-dependent alterations in energy homeostasis in TgF344-AD rats
Listed in Teesside University Research Data Repository
Dataset accompanying the 2026 article: Hypothalamic amyloid levels are associated with early sex-dependent alterations in energy homeostasis in TgF344-AD rats.
Description
We hypothesized a bi-directional relationship between peripheral metabolic impairments and Alzheimer's disease neuropathology. This dataset includes pre and post-mortem measurements from male and female Tgf344-AD rats.
We detected soluble amyloid beta 40 and 42 in the hypothalamus of TgF344-AD rats alongside sex-dependent impairments in peripheral metabolic indices. Amyloid beta 42 positively correlates with separate impaired measures in male versus female TgF344-AD rats. These findings suggest that Alzheimer's disease pathology in the hypothalamus may induce or contribute to peripheral metabolic impairments in a sex-dependent fashion which can then exacerbate AD pathology.
Read the rest (1 more)
The readme text file contains salient information about experimental design and measurements taken.
Links
Where it is published
- DOI doi.org/10.17632/rthpp2ktb7.3 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Earth & Environmental Science · Medicine & Health
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/rthpp2ktb7.3 | 17 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[modality].local:modality:text | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |