Targeted lipidomics and transcriptomics data of white adipose tissue under ER stress

Despite the crucial role lipid plays in regulating adipose tissue function, the specific lipidomic alterations in VAT and SAT under ER stress remain unclear. In this study, ER stress was induced in VAT and SAT, and targeted lipidomic and transcriptomic approaches were applied to assess the profiles of lipid metabolism and gene expression under ER stress condition. .

The results revealed that VAT displayed a more pronounced ER stress response, including a marked increase in binding immunoglobulin protein (BiP) expression, and significant lipidomic disruptions, particularly in glycerides and sterols. These disruptions involved a reduction in protective polyunsaturated fatty acyl species and the accumulation of lipotoxic molecules. While SAT exhibited less severe disruptions in lipid metabolism.