Processed macrophage sequencing data

Processed macrophage sequencing data. Samples include human alveolar macrophages (AMs), tumor-associated macrophages from lung tumors (TAMs), and differentially polarized human monocyte-derived macrophages (MDMs) as detailed in Hoppstädter et al., 2021 (DOI: doi.org/10.1016/j.ebiom.2021.103578). Raw data were deposited in the Gene Expression Omnibus (GEO) database (GEO datasets GSE162669 and GSE162698).

Gene expression clustering was done with hierarchical clustering in R. genes were screened for the enrichment of transcription factor binding using the iRegulon software. Raw counts (TPM) are listed in TMP_all_samples_with_symbols. Genes within clusters are listed in Clusters_GeneIDs, and enrichment of transcription factor binding sites within clusters are given in Clusters_ResultsiRegulon.