Phylogenetic dataset of fowl adenovirus strains circulating in Bangladesh in 2024

In this study, FAdV-8b was identified by PCR and sequencing in multiple organs of naturally infected commercial broiler and broiler breeder flocks. Gross and histopathological lesions included enlarged, friable livers with necrotic foci, hydropericardium, and characteristic intranuclear inclusion bodies in the liver, kidney, spleen, and thymus.

Phylogenetic analysis confirmed that the detected FAdV-8b strains are closely related to other Bangladeshi isolates. Notably, natural infection resulted in significant upregulation of proinflammatory cytokines (IL-6, IL-18, TNF-α) and antiviral IFN-γ, particularly in the liver and spleen, suggesting a strong innate immune response associated with tissue pathology. These findings establish FAdV-8b as the predominant IBH pathogen in Bangladesh and underscore the need for ongoing surveillance and targeted control strategies to mitigate its impact on poultry health and production.