<p>Highlights.</p>

<div> <p>Objective</p><p>To characterize age- and sex-stratified prevalence patterns of obstructive sleep apnea and co-morbid conditions corresponding to components using a large, population-based electronic health record dataset.</p> <p>Study Design</p><p>The study cohort included 556,474 unique de-identified OSA patients (ICD-9 code 327.23), mined from HIPAA-compliant Cerner database (1999–2016). The patient records were mined using Structured Query Language (SQL), stratified by age, gender, and stroke risk comorbidities per , to conduct a population-based cross-sectional epidemiological study.</p> <p>Methods</p><p>Clinical and epidemiological research informatics methodologies are applied to characterize OSA prevalence patterns across age (5-year intervals), gender, and stroke risk comorbidities per criteria.

Body-level organ system involvement was examined according to the Major Diagnostic Category (MDC) classification.</p> <p>Results</p><p>Age-stratified cross-sectional analyses showed that prevalence rates for OSA (m: 10.43%, f: 9.28%), hypertension (m: 7.37%, f: 7.11%), along with clinical encounters, peaked at age 55 for both genders, whereas the highest prevalence of cardiovascular comorbidities was observed in older age groups (ages 65–70).