Omics · study · 2026
The secreted protein MoSun4 of Magnaporthe oryzae regulates pathogenicity by repressing the expression of virulence-related genes
Listed in NCBI GEO
The SUN family protein MoSun4 in Magnaporthe oryzae has been previously implicated in mitophagy and can be used as a target for reducing rice blast, but its role as a secreted protein remain poorly understood.
Description
In this study, signal peptide prediction and yeast secretion assays confirmed the activity of MoSun4 signal peptide, and co-localization revealed its extra-invasive hyphal membrane (EIHM) localization, establishing MoSun4 as a secreted protein.
In addition, deletion of MoSUN4 severely attenuated the hyphal growth, conidiation and virulence of M. oryzae. We further showed that MoSun4 represses the expression of virulence-related genes, including multiple genes involved in cell wall degradation (eglC, eglD), secondary metabolism (gliK), and melanin biosynthesis (SDH1, BUF1, Cmr1, ALB1). Collectively, our study reveals that MoSun4 is a secreted protein and regulates pathogenicity by repressing the expression of virulence-related genes, providing new insights into the function of SUN family proteins.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330356 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330356 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1463700 ncbi.nlm.nih.gov/bioproject/PRJNA1463700 ↗
project · from NCBI GEO
- PubMed 42646132 pubmed.ncbi.nlm.nih.gov/42646132 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
Provenance · 1 source records, 6 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE330356 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |