Data · dataset · 2026
Novel approach cathepsin S-Specific antibody-drug conjugates
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32641908.v1
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with poor survival rates and no effective early detection methods.
Description
Most patients present at an advance stage, where chemotherapy is limited. Antibody-drug conjugates (ADCs) offer targeted delivery of cytotoxic agents, reducing systemic toxicity.
However, current ADCs face issues such as non-specific linker cleavage and lysosomal entrapment. This project developed a novel ADC platform using a Cathepsin S (Cat S)-cleavable linker, chosen for its restricted expression in normal tissues, overexpression in tumours, and stability under physiological conditions. A cleavable substrate was linked to SN-38 via various linkers designed to mimic metabolites that promote lysosomal escape.
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The most active metabolite was then attached to the linker and conjugated to Cetuximab using either acrylamide or bromopyridazinedione (BrPD), with BrPD showing better conjugation efficiency. Future work is needed to identify more selective Cat S substrates and to optimise the conjugation process.<br><br><i>Thesis is embargoed until 31 December 2030</i>.
Links
Where it is published
- DOI doi.org/10.17034/32641908.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 3 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32641908 | 12 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32641908 | 12 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32641908 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |