Genome wide mRNA sequencing data in macrophages without and with CX-5461 treatment

However, the molecular mechanisms underlying the inhibitory effects of CX-5461 on macrophage-mediated inflammation remain to be clarified. In the present study, we attempted to identify the systemic biological processes which were modulated by CX-5461 in inflammatory macrophages.

Primary peritoneal macrophages were isolated from normal Sprague Dawley rats, and primed with lipopolysaccharide or interferon-gamma. Genome-wide RNA sequencing was performed. The study suggests that limiting cell proliferation predominates in the inhibitory effects of CX-5461 on macrophage-mediated inflammation.