Data · dataset · 2026
<p>High-dose/low-stress exposure does not alter body weight or cognition but appears to reduce anxiety in rats.</p>
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.1371/journal.pone.0337157.g002
<p>Rats were exposed to a high dose of chemical agents and a low-stress protocol for five weeks.
Description
Body weight was monitored during GW exposure. At 4−5 weeks post-exposure, rats received either LH-001 or vehicle.
Anxiety-like and cognitive behaviors were assessed starting from 8–9 weeks post-exposure. A two-way ANOVA was used for body weight analysis. A one-way ANOVA was used for behavioral analysis. <b>(A) Body weight.</b> Body weights were monitored weekly over the first four weeks (n = 8 for control and n = 16 for GWI).
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No significant differences were found between groups. <b>(B, C) Open field test.</b> Time spent in the center (B) and total distance traveled (C) were measured (n = 12/group). No significant differences were found between groups. <b>(D) Elevated plus maze test.</b> The percentage of time spent in the open arms was analyzed (n = 8/group). No significant differences were found between groups. <b>(E-F) Dark and light test.</b> Latency to enter the dark chamber (E) and percent of time spent in the light chamber (F) were assessed (n = 8–15/group).
GWI/vehicle rats spent significantly more time in the light area; GWI/LH-001 rats also spent more time in the light area but did not reach significance. <b>(G-H) Novelty-suppressed feeding test.</b> Amount of food consumed (G) and latency to begin feeding (H) were analyzed (n = 11–12/group). GWI/LH-001 rats ate significantly more food than control/vehicle rats; GWI/vehicle rats also ate more food but did not reach significance.
Overall, high-dose/low-stress exposure appeared to reduce anxiety. <b>(I, J) Recognition memory test.</b> Discrimination index scores for novel object location (I) and novel object recognition (J) were calculated (n = 8/group). No significant differences were found between groups. <b>(K-L) Barnes maze test.</b> Latency to find the escape hole (K) and time spent in the target quadrant (L) during the initial training phase were analyzed (n = 8/group).
GWI/LH-001 rats spent less time finding the target hole than GWI/vehicle rats. <b>(M-N) Barnes maze re-training.</b> Latency to the new escape hole (M) and time spent in the new target quadrant (N) were analyzed one week later (n = 8/group). No significant differences were found between groups. <b>(O) Barnes maze memory recall.</b> Time spent in the original target quadrant during the re-training phase was analyzed (n = 8/group).
GWI/rats spent significantly more time in the target quadrant than control/vehicle rats. Overall, high-dose/low-stress exposure did not cause cognitive issues. *<i>p</i> < 0.05.</p>
Links
Where it is published
- DOI doi.org/10.1371/journal.pone.0337157.g002 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Chemistry · Chemistry · Chemistry · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Life Sciences · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Medicine & Health · Psychology & Behavioral Science · Psychology & Behavioral Science · Psychology & Behavioral Science · Research, science and technology policy · Research, science and technology policy · Research, science and technology policy
Provenance · 3 source records, 23 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34034902 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34034902 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/34034902 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:field:440710 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:field:440710 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:field:440710 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].local:field:chemistry | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |