Data · dataset · 2019
Dose-level toxicity and efficacy outcomes from dose-finding clinical trials in oncology
Listed in UBIRA eData
This dataset contains information on the outcomes observed at each dose-level in a large number of dose-finding clinical trials in oncology.
Description
These trials typically seek to identify a maximum tolerable dose or a recommended phase 2 dose. A common rule-based method for conducting such trials is the 3+3 algorithm.
A common model-based alternative is the continual reassessment method (CRM). Each of these methods assumes that as dose is increased, the probabilities of toxicity and efficacy will each increase monotonically. If this assumption is violated, both methods may recommend inappropriate doses.
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For instance, if the probability of efficacy does not increase in dose but the probability of toxicity does, the 3+3 and CRM designs may recommend a dose that is unjustifiably high. The same is true of any design that assumes that "more is better". We collated this dataset to investigate the appropriateness of the monotonicity assumptions in dose-finding clinical trials.
See README or github.com/brockk/dosefindingdata for more information. v1.1 is a minor update correcting typos.
Links
Where it is published
- UBIRA eData record edata.bham.ac.uk/337/5/readme_eData337_KB.docx ↗
landing page · from edata bham ac uk
- UBIRA eData record edata.bham.ac.uk/337/4/Database_v1.3.xlsx ↗
landing page · from edata bham ac uk
- UBIRA eData record edata.bham.ac.uk/337/1/Database.xlsx ↗
landing page · from edata bham ac uk
- UBIRA eData record edata.bham.ac.uk/337/3/Database_v1.2.xlsx ↗
landing page · from edata bham ac uk
- UBIRA eData record edata.bham.ac.uk/337/2/Database_v1.1.xlsx ↗
landing page · from edata bham ac uk
- DOI doi.org/10.25500/edata.bham.00000337 ↗
DOI / persistent id · from edata bham ac uk
Catalogue records · 1
- OAI-PMH record edata.bham.ac.uk/cgi/oai2?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3… ↗
metadata API · from edata bham ac uk
Topics
- From keywords
- Earth & Environmental Science
Provenance · 1 source records, 5 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| UBIRA eData | oai:edata.bham.ac.uk:337 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].local:field:earth-environmental | mapping · edata bham ac uk | connector:edata_bham_ac_uk@1.0.0 | |
| description | source · edata bham ac uk | connector:edata_bham_ac_uk@1.0.0 | /metadata/dc/description |
| license_text | source · edata bham ac uk | connector:edata_bham_ac_uk@1.0.0 | |
| publication_date | source · edata bham ac uk | connector:edata_bham_ac_uk@1.0.0 | |
| title | source · edata bham ac uk | connector:edata_bham_ac_uk@1.0.0 | /metadata/dc/title |