A dataset for oxytocin loaded nanoparticles and their effects on pentylenetetrazole-kindling model of male rats

Memory-related cognitive abnormalities are important problems with this disorder. Pentilentetrazol (PTZ)-kindling is one of the models which is applied on rodents in order to investigate TLE.

Findings for the histopathology of hippocampus are like decrease of neurogenesis, and short-time memory alterations are seen in the PTZ-kindling model which are also related to human TLE. Although exogenously application of oxytocin (OT) hormone researches are increasing for the effects of brain and related pathophysiologies, epilepsy-related studies are highly limited. According to previous data about OT application for non-invasive and efficiently passing through the brain, it is seen that intranasal (IN) pathway and OT loaded nanoparticles (NP-OTs) are prominent methods for that issue.