Data · dataset · 2025
Investigation of loss of Cathepsin B in Niemann Pick disease, type C1
Listed in Teesside University Research Data Repository
Experiments investigating the effect of the loss of Cathepsin B (Ctsb-/-) in Niemann Pick type C1 deficient mice.
Description
Summary
Double mutant mice with the loss of Cathepsin B (Ctsb) and Niemann Pick type C1 (Npc1) were generated and analyzed with respect weight, beam walk, disease severity score and survival. The results were compared to control mice as indicated. Results: Double mutant mice (Ctsb-/-/Npc1-/-) exhibited a reduced weight gain pattern, a more severe balance and coordination assessment, a more severe disease burden and a reduced survival compared to control mutant mice (Ctsb+/-/Npc1-/-).
Read the rest (1 more)
Conclusions: Lack of Cathepsin B in the NPC1 mutant mice increases the severity of the NPC1 disease.
Links
Where it is published
- DOI doi.org/10.17632/h2bvr7ggxr.1 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Earth & Environmental Science · Life Sciences · Medicine & Health
- Inferred from text
- Disease 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/h2bvr7ggxr.1 | 7 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |