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Data · dataset · 2026

<p>Low-dose/low-stress exposure does not alter body weight, anxiety-like behavior, or cognition in rats.</p>

Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.1371/journal.pone.0337157.g001

<p>Rats were exposed to low-dose chemical agents under a low-stress protocol for five weeks.

Description

Body weight was monitored during and after exposure. At 4–5 weeks post-exposure, rats received LH-001 or vehicle.

Anxiety-like and cognitive behaviors were assessed beginning 8–9 weeks post-exposure. Data were analyzed using two-way ANOVA unless otherwise indicated. Unless specified, n = 12 per group. <b>(A) Body weight</b> measured weekly during the first six weeks (n = 24/group).

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No significant differences were observed between groups. <b>(B, C) Open-field test</b>: time spent in the center (B) and total distance traveled (C). <b>(D) Elevated plus maze</b>: percentage of time spent in the open arms. <b>(E, F) Light–dark transition test</b>: latency to enter the dark compartment (E) and percentage of time spent in the light compartment (F) (n = 11–12/group). <b>(G, H) Novelty-suppressed feeding test</b>: food consumption (G) and latency to feed (H) (n = 10–12/group). <b>(I, J) Recognition memory tests</b>: discrimination index for novel object location (I) and novel object recognition (J). <b>(K, L) Barnes maze training</b>: latency to find the escape hole (K) and time spent in the target quadrant (L). <b>(M, N) Barnes maze re-training</b>: latency to locate the new escape hole (M) and time spent in the new target quadrant (N) one week later. <b>(O) Barnes maze memory recall</b>: time spent in the original target quadrant during the re-training probe.

No significant differences were observed between groups in any behavioral measure.</p>

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Where it is published

Catalogue records · 1

Topics

Provenance · 3 source records, 23 field assertions
SourceKeyLast seenRaw
ZivaHuboai:figshare.com:article/340348999 d agoJSON v1
Deakin Research Onlineoai:figshare.com:article/340348999 d agoJSON v1
DMU Figshareoai:figshare.com:article/340348999 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0
concepts[field].anzsrc:field:440710mapping · dro deakin edu auvocabulary-mapper@1.0.0keywords['Science Policy']
concepts[field].anzsrc:field:440710mapping · zivahub uct ac zavocabulary-mapper@1.0.0keywords['Science Policy']
concepts[field].anzsrc:field:440710mapping · figshare dmu ac ukvocabulary-mapper@1.0.0keywords['Science Policy']
concepts[field].local:field:chemistrymapping · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0
concepts[field].local:field:chemistrymapping · figshare dmu ac ukconnector:figshare_dmu_ac_uk@1.0.0
concepts[field].local:field:chemistrymapping · dro deakin edu auconnector:dro_deakin_edu_au@1.0.0
concepts[field].local:field:earth-environmentalmapping · dro deakin edu auconnector:dro_deakin_edu_au@1.0.0
concepts[field].local:field:earth-environmentalmapping · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0
concepts[field].local:field:earth-environmentalmapping · figshare dmu ac ukconnector:figshare_dmu_ac_uk@1.0.0
concepts[field].local:field:life-sciencesmapping · figshare dmu ac ukconnector:figshare_dmu_ac_uk@1.0.0
concepts[field].local:field:life-sciencesmapping · dro deakin edu auconnector:dro_deakin_edu_au@1.0.0
concepts[field].local:field:life-sciencesmapping · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0
concepts[field].local:field:medicine-healthmapping · figshare dmu ac ukconnector:figshare_dmu_ac_uk@1.0.0
concepts[field].local:field:medicine-healthmapping · dro deakin edu auconnector:dro_deakin_edu_au@1.0.0
concepts[field].local:field:medicine-healthmapping · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0
concepts[field].local:field:psychology-behavioralmapping · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0
concepts[field].local:field:psychology-behavioralmapping · dro deakin edu auconnector:dro_deakin_edu_au@1.0.0
concepts[field].local:field:psychology-behavioralmapping · figshare dmu ac ukconnector:figshare_dmu_ac_uk@1.0.0
descriptionsource · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0/metadata/dc/description
licensesource · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0/metadata/dc/rights
publication_datesource · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0
titlesource · zivahub uct ac zaconnector:zivahub_uct_ac_za@1.0.0/metadata/dc/title