Table · dataset · 2026
A Comprehensive Comparison of Coronary Artery Disease Severity Assessment by Coronary Computed Tomography Angiography
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<p dir="ltr">Coronary artery calcification markedly impairs the diagnostic performance of coronary computed tomography angiography (CCTA) by obscuring lumen boundaries and causing overestimation of stenosis severity, especially in complex calcified lesions.
Description
This study evaluated enhanced reconstruction CCTA for obstructive coronary artery disease (CAD) compared with conventional CCTA across reader-experience levels and calcification subtypes.
In this single-center prospective diagnostic accuracy study, 160 patients underwent CCTA and invasive coronary angiography, and 77 patients (48.1%) had obstructive CAD according to the integrated invasive reference standard. Conventional and enhanced reconstruction images were independently interpreted by novice, intermediate, and advanced readers. In the evaluable-case patient-level analysis (n = 155), enhanced CCTA achieved a sensitivity of 93.5%, specificity of 74.4%, negative predictive value of 92.1%, and accuracy of 83.9%, compared with an accuracy of 72.3% for conventional CCTA.
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Across reader groups, AUC values increased from 0.81–0.92 with conventional CCTA to 0.91–0.95 with enhanced CCTA. Enhanced reconstruction also improved diagnostic confidence and showed the greatest benefit in severely calcified lesions and among less experienced readers. These findings indicate that enhanced reconstruction CCTA improves the accuracy and robustness of non-invasive evaluation of complex calcified coronary lesions while reducing, but not eliminating, residual false-positive classifications.</p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.33653632.v1 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Biogeography and phylogeography · Chemistry · Computer Science & AI · Earth & Environmental Science · Economics & Finance · Engineering · Humanities · Life Sciences · Medicine & Health · Ocean & Atmospheric Science · Social Science
- Inferred from text
- Computed tomography 75% · Disease 75% · Image 65%
Provenance · 1 source records, 20 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33653632 | 5 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · figshare com | connector:figshare_com@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:310402 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Biogeography and phylogeography'] |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[modality].local:modality:ct | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:image | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/description |
| license | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |