Pharmacogenomics of GPCR drug targets. Hauser et al.

Summary

Natural genetic variation in the human genome is a cause of individual differences in responses to medications and is an under-appreciated burden on public health. Although 108 G protein-coupled receptors (GPCRs) are the targets of 475 (~34%) FDA-approved drugs, the prevalence of genetic variation among GPCRs targeted by drugs is unknown. By analysing data from 68,496 individuals we find that GPCRs targeted by drugs show genetic variation within functional regions such as drug- and effector-binding sites in the human population.