Norman et al Clostridioides difficile Toxin B subverts germinal center and antibody recall responses by stimulating a drug-treatable CXCR4-dependent mechanism

The PDF attachment included (Norman et al project metadata 110623) lists all information needed to analyze and interpret the raw data and is broken down figure by figure corresponding to its organization in the manuscript. On 04/04/24, this entry was amended to add a PDF of the project metadata corresponding to the manuscript revisions (Norman et al project metadata ADDENDUM 040424) and to add raw data corresponding to new experiments that were added during the course of revision.

On 04/26/24 following provisional acceptance of the revised manuscript, the final dataset was re-uploaded. PROJECT SUMMARY: Recurrent Clostridioides difficile infection (CDI) results in significant morbidity and mortality. We previously established that CDI in mice did not protect against reinfection and was associated with poor pathogen-specific B cell memory (Bmem), recapitulating our observations with human Bmem.