Gut microbiome-based prediction of autoimmune neuroinflammation [* Cross-Reference *]

Nevertheless, assessing presence or the relative abundances of a suspected microbial risk factor failed to predict disease courses across different microbiota compositions. Importantly, we found considerable inter-individual disease course variations between mice harboring the same microbiota. Evaluation of multiple microbiome-associated functional characteristics and host immune responses demonstrated that the immunoglobulin A-coating index of Bacteroides ovatus before disease onset is a robust individual predictor for disease development.

Our study highlights that the “microbial risk factor” concept needs to be seen in the context of a given microbial community network, and host-specific responses to that community must be considered when aiming for predicting disease risk based on microbiota characteristics. ***This entry has been automatically imported via OpenAlex by LIST harvest scripts. Please refer to doi.org/10.1101/2023.04.14.536901 for the original and latest version of the publication***