An injectable Ce-MnCo LDH nanozyme gel with cascade catalytic activity for acute radiation proctitis in rats

Currently, effective clinical treatments that can systematically intervene in ARP are lacking. In this study, we developed an injectable, multicenter cascade nanozyme gel (Ce–MnCo LDH gel) for intrarectal administration to combat radiation-induced intestinal injury.

By atomically integrating cerium (Ce) into the lattice of manganese-cobalt layered double hydroxides (MnCo LDH), we constructed a complex multicenter electron transfer network, endowing the nanozyme with potent, broad-spectrum catalase-, superoxide dismutase-, and glutathione peroxidase-like activities that effectively neutralize various ROS. Ce–MnCo LDH gel exhibited good stability and local retention capacity, effectively alleviated radiation-induced oxidative damage, reduced DNA damage, protected mitochondrial function, and inhibited NF-κB-mediated inflammatory signaling.