Omics · study · 2026
Systematic transcriptomic analysis enables targeted drug repurposing for neurotropic flavivirus infections
Listed in NCBI GEO
Emerging mosquito-borne orthoflaviviruses like WNV and USUV pose global health risks due to rapid spread, severe neurological effects, and the lack of approved antivirals.
Description
This study used transcriptomic and bioinformatic analyses to uncover host–virus interactions and key molecular pathways. Based on these findings, approved drugs with potential antiviral activity were prioritized, and two were selected for experimental validation.
The results highlight how integrating transcriptomic profiling with drug repurposing can accelerate the discovery of antiviral strategies against emerging viruses.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309915 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309915 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1363992 ncbi.nlm.nih.gov/bioproject/PRJNA1363992 ↗
project · from NCBI GEO
- PubMed 42202655 pubmed.ncbi.nlm.nih.gov/42202655 ↗
publication · from NCBI GEO
- PubMed 42618991 pubmed.ncbi.nlm.nih.gov/42618991 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
Provenance · 1 source records, 6 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE309915 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |