Supplementary file 1_Impact of constipation on patients with schizophrenia and depression: an internet-based survey (CONSIDER survey).docx

Multivariable regression analysis showed that schizophrenia and depression were associated with constipation severity. In the schizophrenia and depression groups, current symptom status and anxiolytic use remained independently associated with CSS scores. Across all groups, participants with CSS scores ≥6 had lower Mental Component Summary scores and higher levels of presenteeism, overall work productivity loss, and activity impairment than those with CSS scores ≤5.

Approximately 30% of all participants in each of the schizophrenia and depression groups reported receiving prior explanations regarding psychotropic-related constipation risk, while 40% reported bowel-habit changes after psychotropic drug initiation.</p>Conclusions<p>Constipation severity was higher in participants with schizophrenia and depression than in the general population; greater severity was associated with lower QOL and greater work productivity impairment.

Routine screening, education on constipation, and patient-centered constipation management may be useful clinical approaches for addressing constipation and its associated burden in these populations.</p>Trial registration<p>This study was registered with the University Hospital Medical Information Network (UMIN000058981).</p>