Data · dataset · 2026
The development of next-generation antibody based therapeutics for the treatment of pancreatic cancer
Listed in ZivaHub and Deakin Research Online and DMU Figshare and UCL Research Data Repository — shown once because both records carry DOI 10.17034/32632368.v1
Pancreatic cancer is an extremely challenging disease in dire need of improved detection methods and therapeutics.
Description
Currently, less than 20% of patients are eligible for surgery at the time of diagnosis, the only potentially curative treatment regimen available. Many of the remaining 80%+ of patients lack the physical fitness to tolerate the current first-line chemotherapeutic combination therapy FOLFIRINOX, due to the significant toxicities associated with treatment.
This highlights the urgent need for researchers to identify novel therapeutic agents capable of providing tangible patient benefit in the clinic.<br><br>Increasingly, researchers have acknowledged that in pancreatic cancer, profound disease control is unlikely to be achieved utilising single agent treatment methodologies. Efforts should now focus on the identification and validation of rationale combinations, utilising synergistic mechanisms of action to exploit multiple disease vulnerabilities.
Read the rest (2 more)
Monoclonal antibodies and their derivatives are an avenue worth exploring for utilisation in combination therapeutic approaches. They have previously revolutionised the field of oncology and their potential has not yet been exhausted. A novel potential clinical application of antibodies is their incorporation into nanomedicine platforms as both targeting ligands and effector molecules, to facilitate both improved drug delivery and synergistic signalling for enhanced disease control via ‘active targeting’.<br><br>This thesis attempts to develop and validate novel antibody conjugated, nanoparticle-based delivery systems for cytotoxic payloads.
Alongside this, novel antibodies targeted against a range of targets were also developed, for their incorporation into treatment strategies for pancreatic cancer.<br><br>In summary, this thesis describes the development of a range of antibody-based therapeutics, furthering current understandings of nanoparticle-based delivery systems and the therapeutic potential of next-generation antibody-based therapeutics for the treatment of pancreatic cancer.<br><i><br>Thesis embargoed until 31 July 2027</i>.
Links
Where it is published
- DOI doi.org/10.17034/32632368.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 4 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32632368 | 11 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32632368 | 11 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32632368 | 11 d ago | JSON v1 |
| UCL Research Data Repository | oai:figshare.com:article/32632368 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |