Environmental enrichment resilience the social stress induced anxiety-like behaviour and memory impairment through epigenetic regulation in wild mice Mus booduga

The present study was designed to investigate whether EE can confer resilience against social stress–induced behavioral and molecular alterations in M. booduga. Animals in the experimental groups were subjected to an object recognition memory task, followed by whole-transcriptome analysis of hippocampal tissue samples.

We found that social isolation under chronic stress down-regulated genes involved in stress regulation and synaptic plasticity, whereas EE restored object recognition memory and normalized the expression of these genes