Defining Chicken Host Responses to Spotty Liver Disease

The disease is characterized by a sharp decline in egg production and increased mortality.The characteristic feature is the presence of 1-2 mm white to grey necrotic foci distributed across the liver surface.Despise its impact,the molecular mechanisms underlying host responses to C. hepaticus infection remain poorly understood.To address this gap, we performed a comprehensive analysis using RNA sequencing of liver tissue from naturally infected chickens compared to uninfected controls.