Supplementary file 1_Association between minimum nocturnal heart rate and cerebral small vessel disease in patients with obstructive sleep apnea.docx

This retrospective observational study sought to identify clinical and physiological factors associated with CSVD in adults with OSA.</p>Methods<p>We reviewed adult patients who underwent overnight polysomnography and were diagnosed with OSA at the Sleep Medicine Department of the People's Hospital of Guangxi Zhuang Autonomous Region from January 2021 to December 2023.

Data collected included demographics, polysomnography, biochemical markers, and brain MRI. The primary outcome was the presence of CSVD. Multivariate logistic regression determined independent factors, and model discrimination was assessed with the area under the receiver operating characteristic curve (AUC).</p>Results<p>Among 630 patients, 265 (42%) had CSVD.