Investigation of the <i>in vitro</i> and <i>in vivo</i> immunomodulatory activity helminth effector molecules on bacterial induced infection and inflammation

In particular, some helminth peptides have been shown to preferentially bind to macrophages, augment their function to regulate inflammation and reduce severity in numerous preclinical models of allergic and autoimmune disease.<br><br>Here, we explore the potential of one of these peptides to modulate responses in vitro and in vivo to infection.

Through a peptide screen of several truncated derivatives, we examine macrophage responses to infection following treatment with this peptide and reveal the potential region of bioactivity required for function and highlight scope for future research into therapeutics in the chronic lung disease setting.<br><br><i>Thesis is embargoed until 31st July 2030</i>.<br><br>