Supplementary file 1_Peri-procedural and early body temperature trajectories after endovascular thrombectomy and clinical outcomes in intensive care unit patients with acute ischemic stroke: a retrospective cohort study.docx

Multivariable models adjusted for prespecified baseline and procedural covariates.</p>Results<p>Four trajectories were identified: stable normothermia (n = 89), early transient temperature rise (n = 49), delayed fever (n = 32), and persistent hyperthermia (n = 67). Unfavorable functional outcome occurred in 143 patients (60.3%) and 60 (25.3%) died by 90 days. The global trajectory-class test was significant for mortality (p = 0.019) but not for unfavorable functional outcome (p = 0.088) or post-exposure seizure (p = 0.126).

Compared with stable normothermia, persistent hyperthermia was associated with higher 90-day mortality (adjusted OR 4.51, 95% CI 1.65–12.34). This association was attenuated after adjustment for early antipyretic use (adjusted OR 3.02, 95% CI 0.98–9.32; global p = 0.241) and after exclusion of patients with infection within 72 h (adjusted OR 3.92, 95% CI 1.18–12.97; global p = 0.066). Seizure analyses were exploratory.</p>Conclusion<p>Greater temperature exposure was associated with worse outcomes, consistent with previous work on post-stroke fever.

Persistent hyperthermia was associated with mortality in the primary analysis, but the association weakened in key sensitivity analyses. Trajectory classification did not establish added prognostic value over simpler temperature metrics and should be considered exploratory rather than a new prognostic tool.</p>