Table 1_Uncovering the mortality burden of lung cancer with documented sleep apnea in the United States: a 22-year population-based study.xlsx

The overall AAMR was 0.05 per 100,000 population. Mortality was concentrated predominantly among adults aged 65 years and older and was higher among men, White and non-Hispanic individuals, residents of nonmetropolitan areas, and those living in the Midwest and West. The AAMR increased from 0.011 in 1999 to 0.112 in 2020, with a significant annual percent change of 9.398%.

The ARIMA model projected an increase to 0.160 per 100,000 by 2030, but it consistently overestimated observed AAMRs during 2021–2024 (MAPE 9.71%); therefore, these forecasts were interpreted as conditional and exploratory projections. State-level analyses showed marked geographic heterogeneity not fully explained by socioeconomic development.</p>Conclusion<p>Mortality involving lung cancer and documented sleep apnea increased substantially over 22 years and showed clear demographic and geographic disparities, with a disproportionate burden among older adults, particularly those aged 65 years and above.

The historical trend and exploratory forecasting results support continued attention to sleep health assessment and integrated respiratory-oncology care.</p>