ADAR1 as a Key Regulatory Molecule between MiR-432 and Circ_0000418 in Antidepressant Action

All the data were expressed as the means±SD. The behavior data of C1 group and CUS1 group was analyzed by u test.

In addition, t test was used to analyze the variance for the groups with and without chronic unpredictable stress, the groups with and without ADAR1 target intervention in the mice, as well as the groups with and without transfection in SH-SY5Y cell line. Two-way ANOVA was used to determine whether there is an interaction between chronic unpredictable stress and ADAR1 target intervention (two independent variables) on ADAR1 mRNA expression, BDNF mRNA expression, circ_0000418 expression, and miR-432 expression (dependent variable) respectively among the mice.