Data for : Preoperative Duloxetine to Improve acute pain and quality of recovery in patients undergoing modified radical mastectomy: A dose-ranging randomized controlled trial

Preoperative Duloxetine to Improve acute pain and quality of recovery in patients undergoing modified radical mastectomy: A dose-ranging randomized controlled trial Objective: Duloxetine has been recently used as a part of multimodal analgesia in perioperative settings, yet the optimal dose of Duloxetine is not determined. Design: A parallel, randomized, placebo-controlled trial. Setting: Tertiary level oncology center Patients: 88 female patients with breast cancer were subjected to modified radical mastectomy (MRM) with ASA class I and II were recruited.

Intervention: Participants were randomly allocated into 4 equal groups received 2 hours preoperatively, placebo (D0, N=22), Duloxetine 30 mg (D30, N=22), Duloxetine 60 mg (D60, N=22) and Duloxetine 90 mg (D90, N=22) tablet. Measurements: The primary outcome; 24 h cumulative postoperative morphine consumption and the secondary outcomes; VAS score of pain intensity, quality of recovery (QoR-40), time to Aldrete 9, and side effects (sedation and vomiting) were measured.