Data · dataset · 2025
mRNA expression profile in DLD-1 and MOLT-4 cancer cell lines cultured under Microgravity
Listed in NASA Data Portal
DLD-1 and MOLT-4 cell lines were cultured in a Rotating cell culture system to simulate microgravity and mRNA expression profile was observed in comparison to Static controls.
Description
Cells were grown in 10mL rotating vessels in an RCCS and in 60mm Petri dishes (test control respectively).Two replicates of test (Microgravity) and control (static) each from DLD-1 and MOLT-4 were analyzed by microarray. Simulated microgravity affected the solid tumor cell line DLD-1 markedly which showed a higher percentage of dysregulated genes compared to the hematological tumor cell line MOLT-4.
Microgravity affects the cell cycle of DLD-1 cells and disturbs expression of cell cycle regulatory gene networks. Multiple microRNA host genes were dysregulated and significantly mir-22 tumor suppressor microRNA is highly upregulated in DLD-1.
Links
Get the data
- genelab-data.ndc.nasa.gov /genelab/accession/GLDS-125 ↗
mRNA expression profile in DLD-1 and MOLT-4 cancer cell lines cultured under Microgravity
download · from data nasa gov
Where it is published
- NASA Data Portal dataset page data.nasa.gov/dataset/mrna-expression-profile-in-dld-1-and-molt-4-cancer-cel… ↗
landing page · from data nasa gov
Catalogue records · 1
- CKAN API data.nasa.gov/api/3/action/package_show?id=dbe84807-3000-4730-b7ca-9c180cde8… ↗
metadata API · from data nasa gov
Topics
- Inferred from text
- Cancer 75%
Related
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NASA Data Portal | dbe84807-3000-4730-b7ca-9c180cde8756 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · data nasa gov | keyword-concept-rules@1.0.0 | title+description (75%) |
| created_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| description | source · data nasa gov | connector:data_nasa_gov@1.0.0 | /notes |
| license_text | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| publication_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| title | source · data nasa gov | connector:data_nasa_gov@1.0.0 | /title |
| updated_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 |