Distinct Transcriptomes for Cardiac Repair following multidose intramyocardial administration of Umbilical Cord Blood Mononuclear cells(UCB-MNCs)

In this study, we investigated the transcriptional responses to single versus multidose intramyocardial administration of umbilical cord blood–derived mononuclear cells (UCB-MNCs) in a porcine model of right ventricular pressure overload. Transcriptome profiling revealed distinct gene expression patterns associated with repeated dosing, including activation of pathways related to cardiomyocyte proliferation, angiogenesis, and extracellular matrix remodeling.

Taken together, these data provide a molecular framework for understanding how dosing strategy modulates gene expression programs during cardiac repair and identify novel targets for enhancing the efficacy of regenerative cell therapies.