Data · dataset · 2026
Image 4_Neutrophils suppress adaptive αβ T cells but not the innate γδ T cells and natural killer cells.jpeg
Listed in Deakin Research Online
<p>The presence of polymorphonuclear neutrophils (PMNs) in the tumor microenvironment is associated with lower survival rates for cancer patients.
Description
Presumably due to the immunosuppressive activity of neutrophils (also known as Myeloid-Derived Suppressor Cell (MDSC) activity). We investigated whether this MDSC activity shows any selectivity in suppressing specific lymphocyte subsets.
Our data show that CD4<sup>+</sup> and CD8<sup>+</sup> T cells, both naive and memory fractions, are sensitive to PMN-MDSC activity. Similarly, regulatory T cells, believed to play an important immunosuppressive function themselves, were affected too. In contrast, the more innate-like γδ T cells and Natural Killer (NK) cells were left intact.
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Our data suggest that Chimeric Antigen Receptor (CAR)-NK and γδ CAR-T cell immunotherapy may be less susceptible to PMN-MDSC activity. Therefore, using such MDSC-resistant innate cells as cellular products may be of advantage over the common αβ CAR-T cell therapies. Additionally, further deciphering the exact mechanisms by which neutrophils suppress αβ T cells could lead to improved T cell immunotherapies.</p>
Links
Where it is published
- DOI doi.org/10.3389/fimmu.2026.1977867 ↗
DOI / persistent id · from dro deakin edu au
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from dro deakin edu au
Topics
- From keywords
- Earth & Environmental Science · Life Sciences
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- Possibly the same asImage 3_Neutrophils suppress adaptive αβ T cells but not the innate γδ T cells and natural killer cells.jpeg
- Possibly the same asVideo 1_Neutrophils suppress adaptive αβ T cells but not the innate γδ T cells and natural killer cells.avi
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- Possibly the same asTable 1_Neutrophils suppress adaptive αβ T cells but not the innate γδ T cells and natural killer cells.xlsx
- Possibly the same asVideo 1_Neutrophils suppress adaptive αβ T cells but not the innate γδ T cells and natural killer cells.avi
- Possibly the same asVideo 1_Neutrophils suppress adaptive αβ T cells but not the innate γδ T cells and natural killer cells.avi
- Possibly the same asTable 1_Neutrophils suppress adaptive αβ T cells but not the innate γδ T cells and natural killer cells.xlsx
- Possibly the same asTable 1_Neutrophils suppress adaptive αβ T cells but not the innate γδ T cells and natural killer cells.xlsx
- Possibly the same asVideo 1_Neutrophils suppress adaptive αβ T cells but not the innate γδ T cells and natural killer cells.avi
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Deakin Research Online | oai:figshare.com:article/34038921 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · dro deakin edu au | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[modality].local:modality:image | enrichment · dro deakin edu au | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | /metadata/dc/description |
| license | source · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | /metadata/dc/rights |
| publication_date | source · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| title | source · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | /metadata/dc/title |