Structure · dataset · 2025
Precipitation Profiles of Naproxen in Dissolution Media
Listed in Riga Stradins University dataverse
This dataset contains raw UV absorbance values of naproxen at lambda max (330-334 nm, depending on the polymer), as well as normalised absorbance values (using readings at 850 nm for normalisation).
Description
UV spectra of naproxen was taken in a dissolution media consisting of HCl solution with pH 1.2 (prepared according to Ph. Eur.) supplemented with 2.4% acetonitrile (introduced with naproxen solution).
The media additionally contained one of the following polymers: povidone (PVP K25), copovidone (Kollidon VA 64), poly (butyl methacrylateco-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate 1:2:1 (Eudragit E PO), polyacrylic acid (Apinovex LV), polyvinyl alcohol (PVAl; SRP, 4-88, and 3-82) at a concentration of 0.75 mg/ml (40:60 drug:polymer), and Soluplus at a concentration of 0.125 mg/ml (80:20 drug:polymer).
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Method
A precipitation study was performed in 0.1 N HCl solution with pre-dissolved polymer (60, 40, and 20 wt. %). Naproxen solution in acetonitrile (20 mg/mL) to achieve the proportion of 500 mg of naproxen per 1 L of dissolution medium (0.5 mg/mL) was added. UV absorption was determined directly within 10 mm pathlength quartz cuvettes (at room temperature) with UV spectrophotometer (UV-1900i; Shimadzu Corp., Kyoto, Japan) Spectra were recorded at 5-minute intervals over a 2-hour period (n = 3), using the “Spectrum” or “Time Course” mode in LabSolutions software.
Data. The dataset contains a CSV file of naproxen UV-absorbance values in the presence of polymers. Picture “P1” provides a brief overview of data.
Links
Where it is published
- Dataverse dataset page dataverse.rsu.lv/dataset.xhtml?persistentId=doi%3A10.48510%2FFK2%2FNQENJO ↗
landing page · from dataverse rsu lv
- DOI doi.org/10.48510/fk2/nqenjo ↗
DOI / persistent id · from dataverse rsu lv
Catalogue records · 1
- Dataverse API dataverse.rsu.lv/api/datasets/:persistentId/?persistentId=doi%3A10.48510%2FFK2%… ↗
metadata API · from dataverse rsu lv
Topics
- Stated by source
- Medicine, Health and Life Sciences
- From keywords
- Life Sciences · Materials Science · Medicine & Health
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Riga Stradins University dataverse | doi:10.48510/FK2/NQENJO | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].dataverse_subject:medicine-health-and-life-sciences | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /subjects |
| concepts[field].local:field:life-sciences | mapping · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /subjects |
| concepts[field].local:field:materials-science | mapping · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /subjects |
| concepts[field].local:field:medicine-health | mapping · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /subjects |
| created_date | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | |
| description | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /description |
| publication_date | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | |
| title | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /name |
| updated_date | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | |
| version_label | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 |