The rapid SERS detection of succinylcholine chloride in human plasma is based on the high affinity between quaternary ammonium salt structures

At present, there is a lack of research on its on-site rapid detection methods. In this work, the use of gold nanorods as an enhanced substrate based on the high affinity between the quaternary ammonium salt structure can achieve rapid SERS detection of SCC in plasma.

The long alkane chain structure of cetyltrimethylammonium bromide (CTAB) and the quaternary ammonium salt structure of SCC have a high molecular affinity, so that the target molecule can show a strong and obvious characteristic signal of SERS. Combined with a simple pretreatment method, acetonitrile is used as a protein precipitation agent to effectively remove matrix interference. The constructed SERS substrate can achieve the sensitive detection of 2 × 10-8 M level of SCC in plasma samples and has high detection reproducibility.