Data · dataset · 2024
Continuous AHCC® ingestion suppresses spontaneous carcinogenesis in a murine model
Listed in Teesside University Research Data Repository
AHCC®, a standardized extract of cultured Lentinula edodes mycelia, suppresses the proliferation of both cancer cell line-derived and patient-derived xenografts transplanted into mice.
Description
However, the mechanism of action underlying the suppressive effect of AHCC® on spontaneous carcinogenesis remains unclear. This study investigated the effects of long-term AHCC® ingestion on the health of mice and spontaneous carcinogenesis.
The mice were divided into three groups: A (2% AHCC® ingestion continuously two days a week), B (2% AHCC® ingestion daily), and C (water ingestion). Mice began to ingest AHCC® or water at five weeks of age and were observed until 24 months of age. The onsets of the first death were delayed in the AHCC® ingestion groups and the survival rates were significantly higher than those in the control group.
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The proportion of “healthy mice” with no morphological abnormalities in their organs was also significantly higher in the AHCC® ingestion groups than that in the control group. Furthermore, the incidence of cancer-bearing mice, particularly breast cancer and liver cancer, was significantly reduced in the AHCC® ingestion groups. These results suggest that continuous AHCC® ingestion maintains health and prevents spontaneous carcinogenesis.
Links
Where it is published
- DOI doi.org/10.17632/48kkzrntvr.1 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Cancer · Earth & Environmental Science · Medicine & Health
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/48kkzrntvr.1 | 16 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[disease].local:disease:cancer | mapping · researchdata tees ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |