Data · dataset · 2026
Naproxen Dissolution - Permeation
Listed in Riga Stradins University dataverse and DataverseLV — shown once because both records carry DOI 10.48510/fk2/bckarl
Naproxen tablets dissolution (Nalgesin 550 mg) release profiles and permeation (expressed as apparent permeability coefficient, Papp) across different membrane compositions.
Description
With aim to test novel dissolution-permeation setup and apply it to dissolution-permeation studies of poorly soluble drugs. The dissolution-permeation system setup consisted of a compendial USP2 dissolution apparatus (Double ATSXstend, Sotax, Switzerland), a 6-channel peristaltic pump (LabN1-II/AMC6, Shenchen, China) with silicone tubing, and a CHM1 Ussing chamber with a 1.13 cm2 membrane opening (World Precision Instruments, USA).
Two USP2 vessels were used simultaneously one vessel donor compartment, another acceptor compartment. The Ussing chamber was mounted to an in-house built stand and secured with screws. Silicone tubing (FedroTek, China) Ø2 mm, wall thickness 1 mm was connected to the Ussing chamber ensuring a leak-free system.
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The media pumping flow rate was 6 mL/min. The dissolution study was performed using the pharmacopoeial PBS (1000 mL, pH 6.8, KH2PO4, NaOH). Water bath temperature was set at 37 ºC with a paddle rotation speed of 50 RPM.
Off-line sampling and spectrophotometric quantification was performed over 120 minutes. Dissolution-permeation study. Nalgesin 550 mg tablets were dissolved in 1000 mL pH 6.8 PBS in the donor vessel.
The acceptor vessel contained 1000 mL pH 7.4 PBS (KH2PO4, NaOH). A permeable membrane filter was mounted in the Ussing chamber and covered with soy L-α-phosphatidylcholine solution in dodecane. Permeated naproxen in the acceptor media was UV-quantified on-line with sampling every 15 minutes, up to 180 minutes.
The Papp were calculated from the values on the linear part of the permeation curve.
Links
Where it is published
- Dataverse dataset page dataverse.rsu.lv/dataset.xhtml?persistentId=doi%3A10.48510%2FFK2%2FBCKARL ↗
landing page · from dataverse rsu lv
- Dataverse dataset page dv.dataverse.lv/dataset.xhtml?persistentId=doi%3A10.48510%2FFK2%2FBCKARL ↗
landing page · from dv dataverse lv
- DOI doi.org/10.48510/fk2/bckarl ↗
DOI / persistent id · from dataverse rsu lv
Catalogue records · 2
- Dataverse API dataverse.rsu.lv/api/datasets/:persistentId/?persistentId=doi%3A10.48510%2FFK2%… ↗
metadata API · from dataverse rsu lv
- Dataverse API dv.dataverse.lv/api/datasets/:persistentId/?persistentId=doi%3A10.48510%2FFK2%… ↗
metadata API · from dv dataverse lv
Topics
- Stated by source
- Medicine, Health and Life Sciences · Medicine, Health and Life Sciences
- From keywords
- Life Sciences · Life Sciences · Medicine & Health · Medicine & Health
Provenance · 2 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Riga Stradins University dataverse | doi:10.48510/FK2/BCKARL | 14 d ago | JSON v1 |
| DataverseLV | doi:10.48510/FK2/BCKARL | 13 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].dataverse_subject:medicine-health-and-life-sciences | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /subjects |
| concepts[field].dataverse_subject:medicine-health-and-life-sciences | source · dv dataverse lv | connector:dv_dataverse_lv@1.0.0 | /subjects |
| concepts[field].local:field:life-sciences | mapping · dv dataverse lv | connector:dv_dataverse_lv@1.0.0 | /subjects |
| concepts[field].local:field:life-sciences | mapping · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /subjects |
| concepts[field].local:field:medicine-health | mapping · dv dataverse lv | connector:dv_dataverse_lv@1.0.0 | /subjects |
| concepts[field].local:field:medicine-health | mapping · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /subjects |
| created_date | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | |
| description | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /description |
| publication_date | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | |
| title | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /name |
| updated_date | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | |
| version_label | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 |