Development of preformed photo-crosslinked intravitreal implants for protein delivery to the posterior segment of the eye

The treatment of disorders of the back of the eye, which are collectively referred to as 'posterior segment diseases of the eye,' is made possible by this group of proteins. These disorders include age-related macular degeneration (AMD), diabetic retinopathy (DR), and geographic atrophy, all of which can cause vision impairment and often, blindness.

Controlled delivery systems can minimise the frequency of injections by extending the residence period of active medications at the site of administration. Possible approach is the use of sustained-release implants to give anti-VEGF agents to the patient. <br><br>From investigations carried out in this thesis, PEGDA-based photo-crosslinked intravitreal implants have shown long-term delivery of protein over several months while retaining high protein activity.