Omics · study · 2026
Oral Islatravir in Macaques Decreases Lymphocytes and Monocytes and is Associated with Immune Dysregulation
Listed in NCBI GEO
Treatment and prevention of HIV with oral islatravir (ISL) in humans has been associated with decreases in total lymphocytes, CD4+ T-cells, and B-cells in a dose- dependent manner.
Description
We defined in macaques the effects of oral ISL on lymphocytes, monocytes, granulocytes, and gene expression in peripheral blood mononuclear cells (PBMCs). Female pigtailed macaques (n=5) received an HIV pre-exposure prophylaxis dose of oral ISL adjusted allometrically once a week for 12 weeks.
Complete blood counts and B- and T-cells were monitored prior to, during, and after ISL treatment, and changes in counts were evaluated by using a repeated measures model. ISL treatment was associated with declines in lymphocytes (11.9%, p=0.0015) and monocytes (22.4%, p=0.0003) but not granulocytes (0.3%, p=0.9781). Total lymphocytes and monocytes returned to pre-treatment levels 6 weeks after treatment cessation (p=0.8244 and p=0.4620, respectively).
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Lymphocyte subpopulation analyses showed a significant decline in CD8+ (8.8%, p=0.0403) and CD20+ (73.4%; p<0.0001) cells but not CD4+ cells (0.1%; p=0.9989). Gene set enrichment analysis in PBMCs showed negative enrichment (padj<0.05) of gene pathways associated with immune regulation, cell proliferation, and inflammation. These results provide the first insights on the mechanisms of ISL-induced lymphopenia and highlight the value of the macaque model to study immune alterations at the preclinical stage.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE320nnn/GSE320114 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE320114 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1426401 ncbi.nlm.nih.gov/bioproject/PRJNA1426401 ↗
project · from NCBI GEO
- PubMed 41900867 pubmed.ncbi.nlm.nih.gov/41900867 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
Provenance · 1 source records, 6 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE320114 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |