Omics · study · 2026
Altered expression profile of miRNAs in canine inguinal testes
Listed in NCBI GEO
Cryptorchidism is a major disorder of sex development (DSD) in dogs, with a complex, polygenic background.
Description
It is known that in canine undescended testes expression of protein coding genes is massively up- or down-regulated and it is associated with certain epigenetic modifications. In the present study we aimed to compare expression profile of small non-coding RNAs (sncRNAs) in undescended (UD) and descended (D) testes.
Undescended (UD) and descended (D) testes of unilateral, inguinal cryptorchid dogs (n=9), as well as scrotal testes of control dogs (C, n=8) were analyzed by small non-coding RNA sequencing (sncRNA-seq) approach. Comparison of UD and D testes revealed 224 differentially expressed miRNA (DEGs), with 118 meeting the criteria of FDR < 0.05 and |log2FC| > 1.5 (8 up- and 110 downregulated). Similarly, comparison of UD and C testes identified 200 DEGs, with 102 meeting the same criteria (9 up- and 93 downregulated).
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308086 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308086 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1328723 ncbi.nlm.nih.gov/bioproject/PRJNA1328723 ↗
project · from NCBI GEO
- PubMed 42409905 pubmed.ncbi.nlm.nih.gov/42409905 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Non-coding RNA profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE308086 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:non-coding-rna-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |