Omics · study · 2026
Hypoxia-induced FTO nuclear export promotes m6A-dependent NMNAT3 mRNA stabilization and intracellular NAD+ accumulation in porcine granulosa cells
Listed in NCBI GEO
Hypoxia is a central feature of the follicular microenvironment and influences granulosa-cell metabolism.
Description
This study profiled transcriptome-wide m6A enrichment and RNA abundance in primary porcine granulosa cells cultured under normoxia or hypoxia. Integrative MeRIP-seq and input RNA-seq identified NMNAT3 as a hypoxia-responsive transcript with increased m6A enrichment and expression, supporting a hypoxia-responsive FTO-m6A-NMNAT3 regulatory axis linked to intracellular NAD+ accumulation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342567 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342567 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1508221 ncbi.nlm.nih.gov/bioproject/PRJNA1508221 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Other · Sus scrofa
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE342567 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9823 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |