Table · dataset · 2026
Data Sheet 1_A pH-responsive and self-healing CEC/PEG-(CHO)2 hydrogel for controlled neuropeptide S delivery and endogenous neural repair after spinal cord injury.docx
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<p>A pH-responsive CEC/PEG-(CHO)<sub>2</sub> hydrogel scaffold was engineered for local delivery of neuropeptide S (NPS) to modulate the hostile microenvironment after spinal cord injury (SCI).
Description
The scaffold exhibited accelerated degradation under acidic conditions mimicking the injured site, enabling controlled release of NPS. Its porous microstructure (50−150 μm pore size) and compressive elastic modulus (0.081 MPa, slightly softer than that of a native spinal cord) provide a mechanical microenvironment conducive to neuronal survival and differentiation.
In a T11 complete transection mouse model, the NPS-loaded scaffold significantly attenuated local inflammation (reduced MMP-9, TNF-α, CD68; increased IL-10), suppressed glial scar formation, recruited endogenous Nestin<sup>+</sup> neural stem/progenitor cells (NSPCs), and promoted their differentiation into mature MAP2<sup>+</sup> neurons with enhanced myelination (MBP<sup>+</sup>) and synaptic integration (SYP<sup>+</sup>/MAP2<sup>+</sup>).
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These effects were mediated through the NPS-NPSR axis and downstream Ca<sup>2 +</sup>/cAMP signaling pathways. This study demonstrates that a rationally designed pH-responsive hydrogel can effectively remodel the SCI microenvironment and activate endogenous neural repair mechanisms, offering a promising strategy for SCI treatment.</p>
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Where it is published
- DOI doi.org/10.3389/fnins.2026.1933351.s001 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
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Provenance · 1 source records, 17 field assertions
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