Supplementary file 1_Early blood pressure outcomes after SPYRAL™ renal denervation: an exploratory small cohort analysis.docx

This study aimed to evaluate the effects of the SPYRAL™ catheter system on systolic (SBP) and diastolic blood pressure (DBP) in a real-world clinical setting. Additionally, we explored whether the number of ablation points was associated with the magnitude of blood pressure (BP) reduction.</p>Methods<p>We conducted a retrospective, single-center study including patients aged ≥18 years with predominantly resistant hypertension with preserved renal function (eGFR ≥40 mL/min/1.73 m2) and no evidence of secondary hypertension.

Ambulatory blood pressure monitoring (ABPM) and renal function were assessed at baseline and three months after RDN. Patients were stratified into subgroups based on the number of ablation points (≤20 vs. >20). A two-tailed p-value <0.05 was considered statistically significant.</p>Results<p>Data from eleven patients (mean age 64.4 ± 8.1, 45.5% were male) were analyzed.