<p>Posterior probability versus score plots using DVD derived likelihood and prior probability of pathogenicity.</p>

The intersection of those posterior lines represents the point at which a given REVEL or CADD score provides evidence towards either a benign (BP4) or pathogenic (PP3) classification. Fig 3A shows the benign REVEL score thresholds, Fig 3B shows the pathogenic REVEL score thresholds, Fig 3C shows the benign CADD score thresholds, and Fig 3D shows the pathogenic CADD score thresholds.

Fig B in the <a href="plosgenetics.org/article/info:doi/10.1371/journal.pgen.1012085#pgen.1012085.s001" target="_blank">S1 Appendix</a> shows the tolerance-based plots.</p>