Data Sheet 1_Dynamic γδ T-cell Receptor remodeling and antigen-induced T-cell IFN-γ responses after SARS-CoV-2 infection during pregnancy: insights for γδ T-cell immunotherapy.docx

Maternal T cells retained antigen-inducible IFN-γ responses, with the strongest responses observed in the 90–120-day group. Immune phenotyping revealed interval-associated remodeling of adaptive T-cell subsets, γδ T-cell receptor phenotypes, NK-cell subsets, and selected B-cell compartments. Cord blood IgM remained consistently low, providing no immunological evidence of intrauterine SARS-CoV-2 infection.

In contrast, maternal and cord blood IgG levels were positively correlated, indicating preserved transplacental IgG transfer without clear time-dependent changes in transfer efficiency.</p>Conclusions<p>These results extend current understanding of post-infection immune adaptation during pregnancy and provide an immunological basis for future longitudinal studies aimed at defining the timing and durability of maternal and neonatal immune protection.</p>