Data · dataset · 2025
Summary statistics for pQTL in UKB-PPP
Listed in ScienceDB
Description
Based on strict quality control, we only included 33,325 European participants (17,988 females and 15,337 males), with 2,919 plasma proteins imputed using the mean value. We introduce ProteoNexus (proteonexus.com/), a new platform that characterizes genetic architecture, constructs the prediction model for incident diseases, and estimates the mediation effect of plasma proteins using UK Biobank (application ID: 144904).
In pQTL analysis, ProteoNexus used GEMMA to estimate the summary statistics by adjusting covariables (i.e., age, sex, and the top 18 genetic principal components) and employed SuSiE to calculate probability in posterior (PIP) for each SNP and to estimate the credible sets for each locus.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.26857 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Mathematics & Statistics · Social Science
- Inferred from text
- Genetics 71%
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.26857 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (71%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |